Best Western


401 N 3rd Street, Hannibal, MO 63401-3301
Phone: 573/248-1150   |   Fax: 573/248-1155   |   77 Rooms
Check Out Time: 11:00 AM   |   Check In: 2:00 PM   |   Online Reservations

Welcome to BEST WESTERN PLUS On the River!

Close to the Mississippi River, our Hannibal hotel is also near the Mark Twain Boyhood Home and Museum so guests can see the inspiration and the beginnings of one of America’s literary greats.

Our Hannibal hotel is located in the downtown area, the perfect place for guests to walk around the neighborhood and explore on foot. We’re close to shopping, dining and bars, making it as easy for our guests to get the full experience of the region as possible. When you’re close to attractions, it’s easy to make the most of your trip and see it all.

Another reason many guests stay at our Hannibal hotel is because they have business to take care of at Hannibal-LaGrange University, only a short distance away. We regularly welcome visiting students, faculty and staff. With free high-speed Internet and an indoor pool and hot tub, you’ll feel right at home and have everything you need for a seamless trip.

July 4th weekend is a big celebration in this area, and many out-of-towners stay at our Hannibal hotel to enjoy the festivities. The Hannibal Caveman baseball team is a source of great pride, and you deserve to stay in cool, comfortable accommodations if you’re in town to catch a game. Whether you’re here for the Fall Fest, jet skiing or on business, rest assured you’ll be treated like family here.

A few of our regular Hannibal hotel guests are employees of Hannibal Regional Hospital, General Mills, Buckhorn Rubber® or BASF. Even if you’re here for a vacation, though, it’s important to fill up with a hearty all-American breakfast, and it’s on us. Our free hot breakfast includes your favorites like hot waffles and eggs, pastries and fresh fruits, a selection of cereal and yogurt choices. Complete your meal with 100% Arabica coffee or your juice of choice. It’s the best way to get a great day started.

Reserve your conveniently located room at BEST WESTERN PLUS On the River today and enjoy the trip!


Hotel Amenities & Services

  • 100% smoke-free hotel
  • 24-hour front desk
  • Complimentary full breakfast, choice of breads, cereal, fruit, hot eggs, hot breakfast meat, other hot items, yogurt, juice and coffee.
  • Indoor pool
  • Hot tub
  • Stair stepper
  • Stationary bike
  • Treadmill
  • Free wireless internet available in public areas; Free in-room wireless internet access; Free wireless internet access available in public areas and all guest rooms
  • Cable or satellite television
  • Mail services, mail box at the front desk
  • Air-conditioning
  • Elevator, wheelchair accessible
  • Parking for the physically challenged
  • Cold weather hook-ups
  • Ice/vending machines
  • Truck/RV parking
  • Higher rates may apply for holidays/special events
  • Interior corridor
  • Business center
  • Printer available
  • Fax services, at the front desk
  • Computer available
  • Photocopy, nominal fee
  • Dataports
  • Meeting facilities
  • Network/Internet printing
  • Outdoor parking
  • Free parking
  • Exercise facility, Open from 9:00 a.m. to 10:00 p.m.


Take advantage of the savings and fun with this special offer available at the best western plus on the river in Hannibal.


Conveniently located, the best western plus on the river in Hannibal, Missouri is shown on the map. Detailed driving directions from popular points or nearby cities are listed below. For those with GPS, here you go:

Longitude: 39.711735  /  Latitude: -91.358805


Driving Directions to Hotel


From: Lambert Airport, St. Louis Take Interstate 70 West to Highway 61 North. Turn right on Interstate 72 East and take Exit 157, turn right, Mark Twain Avenue runs into Highway 79. The BEST WESTERN PLUS On The River is located on the right.

From: Quincy Airport. Take Interstate 72 West/US-36 West, take the MO-79/US 36-BR Exit, take Exit 157 toward Louisiana/downtown Hannibal. Turn left onto US-36 BR/US-61 BR/MO-79. The BEST WESTERN PLUS On The River is located on the right.

From: Burlington, IA. Take US-61 South toward Hannibal. Merge onto Interstate 72 East/US-36 East/US-61 BR South/Mark Twain Avenue via the ramp on the left toward Springfield, IL. Take the US-36-BR/US-61 BR/MO-79 South Exit, then take Exit 157 toward Louisiana. Turn slightly right onto US-36 BR/US-61 BR/Mark Twain Avenue. The BEST WESTERN PLUS On The River is located on the right.


We care about the quality of your stay with us. Below are nearby attractions, shopping and restaurants that are popular with our guests. Listed locations are nearby with approximate distance listed where available.

Most Popular Area Attractions

Hannibal-LaGrange University

Established in 1858, Hannibal-LaGrange University is located near the Mississippi River in the eastern Missouri community of Hannibal. Under the motto “Scientia ad serviendum” or "Knowledge for Service,” the institution enrolls students in degree programs like Communication Arts and Criminal Justice.

The HLGU Trojans don scarlet and navy blue as they compet in the National Association of Intercollegiate Athletics in the American Midwest Conference. The list of notable HLGU alumni includes NBA coaching legend Cotton Fitzsimmons.

More Area Attractions & Services

  • 0.10 mile(s) from Twainland Express Sightseeing
  • 0.10 mile(s) from The Mark Twain House & Museum
  • 0.10 mile(s) from Planters Barn Theater, Mark Twain himself shows
  • 0.10 mile(s) from Hannibal Trolley Company, sightseeing tours
  • 0.10 mile(s) from Tom & Huck Statue
  • 0.10 mile(s) from Mark Twain Lighthouse
  • 0.20 mile(s) from Spratt Theater, dinner and show
  • 0.30 mile(s) from Marina Facilities
  • 0.30 mile(s) from Mark Twain River Boat, sightseeing cruises on the Mississippi River
  • 0.40 mile(s) from Molly Brown Birthplace & Museum
  • 0.60 mile(s) from Rockcliffe Mansion
  • 0.10 mile(s) from T'S & Trivia
  • 0.10 mile(s) from Rags To Riches, pawnshop
  • 0.20 mile(s) from Native American Trading
  • 0.20 mile(s) from Ayers Pottery
  • 0.20 mile(s) from Groomingdales, pet boutique
  • 0.20 mile(s) from Hickory Stick Quilt Shop
  • 0.40 mile(s) from The Opened Book, comics, unique creations of gifts, books, incense, candles, jewelry, herbs etc.
  • 2.00 mile(s) from Steamboat Shopping Center
  • 3.00 mile(s) from Huck Finn Shopping Center
  • 3.00 mile(s) from Riverbend Shopping Center
  • 20.00 mile(s) from Quincy Mall

Distances to Popular Points of Interest

  • 20 mile(s) from Quincy, IL
  • 70 mile(s) from Nauvoo, IL
  • 98 mile(s) from Columbia
  • 100 mile(s) from St Louis
  • 100 mile(s) from Springfield, IL
  • 106 mile(s) from Jefferson City
  • 108 mile(s) from Burlington, IA
  • 147 mile(s) from Lake of the Ozark
  • 295 mile(s) from Branson
  • 300 mile(s) from Chicago, IL
  • 300 mile(s) from Indianapolis, IN
  • 383 mile(s) from Louisville, KY
  • 461 mile(s) from Nashville, TN
  • 477 mile(s) from Little Rock, AR
  • 512 mile(s) from Green Bay, WI
  • 641 mile(s) from Minneapolis, MN
  • 670 mile(s) from Atlanta, GA
  • 679 mile(s) from Dallas, TX
  • 864 mile(s) from Houston, TX
  • 4.00 mile(s) from Continental Cement Company
  • 4.00 mile(s) from Altorfer Inc..
  • 5.00 mile(s) from Buckhorn Industries, rubber products
  • 5.00 mile(s) from Watlow Industries
  • 5.00 mile(s) from General Mills
  • 5.00 mile(s) from Hannibal Clinic
  • 5.00 mile(s) from James E. Cary Cancer Center
  • 5.00 mile(s) from Hannibal Regional Hospital
  • 9.00 mile(s) from BASF Corporation, Hannibal site
  • 20.00 mile(s) from Pace Industries Leggett & Platt Aluminum Group
  • 2 mile(s) from Hannibal-LaGrange College
  • 3 mile(s) from Moberly Area Community College, Hannibal campus
  • 20 mile(s) from Quincy University
  • 20 mile(s) from John Wood Community College
  • 20 mile(s) from Vatterott College
  • 20 mile(s) from Blessing Rieman College of Nursing
  • 30 mile(s) from Culver-Stockton College
  • 70 mile(s) from Moberly Area Community College, Moberly campus
  • 80 mile(s) from Westminster College
  • 100 mile(s) from University of Missouri

Local Area Recreation Opportunities

  • Indoor pool
  • Hot tub
  • 0.5 mile(s) from Clemens Field
  • 0.9 mile(s) from Community Swimming Pool
  • 2.00 mile(s) from YMCA
  • 2.00 mile(s) from Riverview Park
  • 2.00 mile(s) from Mark Twain & Cameron Cave
  • 2.00 mile(s) from Sawyers Creek fun park, 18-hole miniature golf course and bumper boats
  • 3.00 mile(s) from American Legion Golf Club, 9 hole golf course
  • 3.00 mile(s) from Huckleberry Park, skate park tennis,frisbee golf,
  • 7.00 mile(s) from Norwoods Golf Club, 18 hole golf course

Nearby Restaurants

  • Across the street from Mark Twain Dinette, Full Service, American, Open for: breakfast, lunch, dinner,
  • 0.1 mile(s) from Ole Planters, Full Service, American, Open for: lunch, dinner,
  • 0.2 mile(s) from Brick Oven, Bar/Lounge, Italian, Open for: lunch, dinner,
  • 0.2 mile(s) from Breadeaux Pizza, Full Service, American, Open for: lunch, dinner,
  • 0.2 mile(s) from Lulabelles, Full Service, American, Open for: lunch, dinner,
  • 0.2 mile(s) from Jumping Frog, Deli, American, Open for: lunch,
  • 2 mile(s) from TJ's Supper Club, Full Service, American, Open for: lunch, dinner,
  • 2 mile(s) from Gran Rio, Full Service, Mexican, Open for: lunch, dinner,
  • 2 mile(s) from Royal Garden, Full Service, Chinese, Open for: lunch, dinner,
  • 5 mile(s) from Fiddlestik, Full Service, American, Open for: lunch, dinner,


Enjoy your stay with us even more by checking out some of the most popular area points of interest and local area events happening in or near Hannibal. Chase the links to explore the local region even more.

Local Events Worth Considering:

July 2014

July 22-28, 2014
Seussical The Musical

Join the Cat in the Hat and other Dr.Seuss characters under the stars at The Muny in Forest Park. Curtain is at 8:15 p.m.

August 2014

August 16 – 20, 2014
2014 GEICO Motorcycle Hot Bike Tour

The annual GEICO Motorcycle Hot Bike Tour is a five-day, 1,000-mile tour – stopping in Joplin and Missouri's capital of Jefferson City, Springfield, Illinois, Bettendorf, Iowa, and Wisconsin Dells, Wisconsin. The event features bike shows, live music, great food, and plenty of vendors.

September 2014

September 6, 2014
3rd Annual Prison Break Race It is time to test your theories of how you would break out of jail. After that task is complete don’t forget the rest of the escape. Join in on the masses escaping from Missouri State Penitentiary and then running the five-mile course filled with obstacles. Registration begins at 7:30 a.m.
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